Scientific Program

Scientific Program

Wednesday, November 15th 2017


13:30-14:45: Arrival, registration & welcome coffee


14:45:-14:45 Welcome note and opening


Session I: Therapy Stratification (Chairs: Oliver Hahn & Philipp Ströbel)


15:00-15:30: Christian Reinhardt (Cologne, Germany)
Targeting the DNA damage response for personalized cancer therapy


15:30-16:00: Christopher Lord (London, UK)
Synthetic Lethality – BRCA and beyond


16:00-16:30: Nabeel Bardeesy (Boston, USA)
Targeting alternative drivers in KRAS mutant pancreatic cancer


16:30-16:45: Coffee Break


Session II: Tumor Genetics I (Chairs: Hanibal Bohnenberger & Matthias Dobbelstein)


16:45-17:15: Matthias Altmeyer (Zürich, Switzerland)
Transcription-replication interference in hyperproliferative cancer cells


17:15-17:45: Martin Eilers (Würzburg, Germany)
MYC-dependent control of RNA Polymerase function during the cell cycle




Thursday, November 16th 2017


Session III: Tumor Immunology (Chairs: Anne Kauffels & Michael Schön)


9:00-9:30: Florian Kühnel (Hannover, Germany)
Oncolytic viruses and checkpoint inhibition close the cancer immunity cycle


9:30-10:00: Stefan Fichtner-Feigl (Freiburg, Germany)
Barrier function and colon cancer biology


10:00-10:30: Coffee Break


10:30-11:00: Thomas Tüting (Magdeburg, Germany)
Upregulation of HGF/c-MET signaling as a resistance mechanism in cancer immunotherapy


11:00-11:30: Dirk Jäger (Heidelberg, Germany)
Using the patient’s immune system to treat cancer


11:30-13:00: Flash Talks and Poster Session


13:00-14:00: Lunch Break


Session IV: Tumor Environment & Metastasis (Chairs: Lena-Christin Conradi & Elisabeth Zeisberg)


14:00-14:30: Sebastian Zeißig (Dresden, Germany)
Calcineurin in intestinal tumor development


14:30-15:00: Alan McIntyre (Nottingham, UK)
Targeting molecular adaptation in the hypoxic tumor microenvironment


15:00-15:30: Thomas Brabletz (Erlangen, Germany)
Cellular plasticity in cancer: driving force and therapeutic target


15:30-16:00: Coffee Break


Session V: Tumor Genetics II (Chairs: Ramona Schulz-Heddergott & Bernd Wollnik)


16:00-16:30: Marco Gerlinger (London, UK)
Dissecting cancer Evolution: Patterns, dynamics and clinical implications


16:30-17:00: Jan Korbel (Heidelberg, Germany)
Germline determinants of the somatic mutation landscape in 2,642 whole cancer genomes


„Get together“ in the Haus am See Göttingen


19:00: Dinner & Entertainment (bus transfer leaves from the conference venue and the hotel “Central” at 18:30)




Friday, November 17th 2017


Session VI: Tumor Epigenetics (Chairs: Elisabeth Hessmann & Steven A. Johnsen)


9:00-9:30: Panagis Filippakopoulos (Oxford, UK)
Modulation of transcription through disruption of BET complexes


9:30-10:00: Udo Oppermann (Oxford, UK)
Inhibiting histone demethylases to target metabolic dependencies in multiple myeloma


10:00-10:30: Rab Prinjha (Stevenage, UK)
Drugging transcription: Progress and potential for treating human diseases


Session VII: Tumor Metabolism (Chairs: Volker Ellenrieder & Robert Götze)


10:30-11:00: Peter Carmeliet (Leuven, Belgium)
Angiogenesis revisited: Role and therapeutic implication of endothelial metabolism


11:00-11:30: Roland Schüle (Freiburg, Germany)
Make my metabolism: Prostate cancer unplugged


11:30: Concluding Remarks, Lunch & Farewell